Many patients wonder: can I take semaglutide at night
Among 1961 patients without T2DM in the STEP 1 trial, the mean reduction in body weight from baseline was 14.9% and 2.4% at 68 weeks of follow-up in patients treated with semaglutide 2.4 mg and placebo, respectively ( P 1 weight reported during the 30-day window for a given follow-up time point, the closest weight to the time point of interest was utilized
Then in May 2025, the first direct head-to-head trial SURMOUNT-5 was published in the New England Journal of Medicine , putting the two medications head-to-head in the same patients, at the same time, under the same conditions
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Higher doses produce greater appetite suppression but also increase the likelihood of gastrointestinal side effects