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These effects are dose dependent, typically occur during treatment initiation or dose escalation, and often improve over time

Huang, T., Zhang, K., Sun, L., Xue, X., Zhang, C., Shu, Z., Mu, N., Gu, J., Zhang, W., Wang, Y., Zhang, Y., & Zhang, W

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Abstract Although the core concept of remyelination based on the activation, migration, proliferation and differentiation of CNS progenitors has not changed over the past 20 years, our understanding of the detailed mechanisms that underlie this process has developed considerably