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As mentioned previously, patients with CSU have increased levels of emotional distress with an underlying anxiety, depression and somatoform disorder [12]

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Discontinuation rates trended higher than with semaglutide or tirzepatide, and TRIUMPH-4 flagged a dysesthesia signal (abnormal skin sensations) in up to roughly 21% of participants on 12 mg versus about 0.7% on placebo

Track your body composition (not just scale weight) monthly to verify that muscle loss isn't occurringif you're eating in a deficit and training hard, creatine helps tip the scale toward muscle retention

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Nature (2009) 460:74852.10.1038/nature08185 24 PurcellSMMoranJLFromerMRuderferDSolovieffNRoussosPet alA polygenic burden of rare disruptive mutations in schizophrenia