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Matt Segar, cardiologist and member of our Medical Review Board, says, Its also worth noting that studies also showed an increase in pulmonary embolism, acute kidney injury, and atrial fibrillation.30 Transdermal testosterone treatment doesnt cause the kinds of supratherapeutic peaks you often see with injected testosterone replacements.18 Unfortunately, the creams have their own set of dangers

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And there are definitely groups who should avoid pre-workouts altogether or at least use caution, including those with cardiovascular conditions, sensitivity to stimulants, or those taking medications (like blood pressure medications) that could interact

Several factors affect these outcomes beyond just the medication itself