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It is not approved for human consumption , diagnosis, treatment, or prevention of any disease.

Crohn's disease, coeliac disease, and conditions affecting stomach or small intestine can impair B12 absorption regardless of dietary intake

Cell signaling and receptors with resorcinols and flavonoids: redox, reactive oxygen species, and physiological effects

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To reach their target area through digestion route makes these pills have less effective absorption rates hence delaying time taken for them to become active