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Studies show that both semaglutide and topiramate are effective for long-term weight loss and can help improve other health issues related to obesity

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Curcumin upregulates GAS5, which can reduce miR-10b and thereby reduce BDNF mRNA levels, or it may increase serotonin (5-HT) and dopamine levels and inhibit monoamine oxidase (MAO-A and MAO-B)