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In some embodiments, the otic formulation or composition comprises about 0.01% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

however, over-expression of GPX4, could reduce the brain water content and improve neurological behavior by suppressing ferroptosis (Gao et al., 2020)

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The trial also found combining B 2 and folic acid decreased levels of alanine transferase, a liver enzyme released during liver cell breakdown, while folic acid alone increased alanine transferase levels