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The Phase 2 obesity trial published in the New England Journal of Medicine reported substantial weight reduction over 48 weeks, while a separate Phase 2 trial in people with type 2 diabetes evaluated glycemic and body-weight effects

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When ultraviolet rays penetrate the skin and damage DNA, thymidine dinucleotide (pTpT) fragments from damaged DNA will trigger melanogenesis [26] and cause the melanocyte to produce melanosomes, which are then transferred by dendrites to the top layer of keratinocytes

doi: 10.1038/ijo.2012.227 66 TanTMFieldBCMcCulloughKATrokeRCChambersESSalemVet al