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The most recent synthesis, a 2025 review by Sikiric and colleagues in Pharmaceuticals (Basel) , addresses BPC-157 as a modulator of angiogenesis and the nitric oxide system

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According to a peer-reviewed clinical review in the National Library of Medicine summarizing GHK-Cus role in tissue remodeling and skin regeneration, the peptide has been documented in clinical research since the early 1970s and remains one of the most validated copper-binding peptides in dermatologic use

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