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Several human studies have demonstrated that supplementing standard-of-care chemotherapies (such as cisplatin, doxorubicin, cyclophosphamide, and busulfan) with Se (in the form of sodium selenite or organic selenium) reduces toxicity without compromising therapeutic efficacy [310]
10.1016/j.dsx.2019.03.020 245
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Retinaldehyde is then oxidized to generate retinoic acid in the presence of the aldehyde dehydrogenase 1 (ALDH1) family enzyme, which is then converted into the product 4-oxo retinoic acid
Gesammelte Abhandlungen zur wissenschaftlichen Medicin (Meidinger, 1856)
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