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Significant weight lossdefined as 5% or more of baseline body weighttypically occurs by 12-16 weeks

During weight loss, the body is mobilizing stored fat for energy

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Importantly, Zepbound carries a Boxed Warning for risk of thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)