A 2019 randomized controlled trial of lipotropic injections (methionine, inositol, choline, B12) versus saline placebo in 120 participants on ad libitum diets found 0.8 kg (1.76 pounds) difference at 12 weeks, not statistically significant (p=0.18) (Karbalay-Doust et al., Journal of Research in Medical Sciences , 2019)
If youre experiencing fatigue, weakness, or difficulty concentrating, B12 shots may be a helpful solution
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Third, the reduced caloric intake that comes with appetite suppression means less dietary B12 enters the system to begin with
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The appropriate choice depends on individual health goals, risk factors, contraindications, and preferences regarding the balance between potential benefits and side effect profiles