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The available human data comes from smaller studies, often unblinded, and primarily from the Khavinson group

In the atherosclerotic process, alongside these known risk factors, the theory of a gutsystemic circulation axis, characterized by the passage in the bloodstream of bacterially derived products, such as LPS and trimethylamine-N-oxide (TMAO), is increasingly emerging [61]

No home test can measure potency directly, but appearance combined with exposure timeline provides reliable assessment

Gut (2010) 59(8):114353

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What the evidence does not establish: Human efficacy at clinically meaningful magnitudes, long-term safety, cardiovascular profile under chronic dosing