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Participants were randomized in a 1:1:2 ratio to receive once-weekly retatrutide 9 mg, retatrutide 12 mg, or placebo for 80 weeks, with treatment initiated at 2 mg and gradually escalated every four weeks to the assigned maintenance dose

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The significant changed metabolites were distributed as organic acids, amino acids and sugar alcohols, and 12 common metabolites were altered after Asian ginseng and American ginseng exposure

In a rodent model of accelerated aging, EGCG supplementation lowered glucose and insulin levels

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These medications mimic the natural actions of GLP-1, improving insulin secretion, enhancing glucose management, and promoting weight loss in patients with type 2 diabetes or obesity