Body-weight variability and risk of cardiovascular outcomes in patients with type 1 diabetes: a retrospective observational analysis of data from the DCCT/EDIC population
Raun and colleagues (Eur J Endocrinol, 1998) characterised it as the first growth hormone releasing peptide with selectivity approaching that of GHRH itself, reporting growth hormone release without the accompanying ACTH and cortisol elevation seen with earlier compounds in the class such as GHRP-6 and hexarelin
This appetite suppression plays a key role in their effectiveness for weight loss
Regular follow-up appointments allow for ongoing assessment of treatment response, side effects, and any new symptoms
That being said, rather than utilizing GLP-1 agonist medications as a first or singular line of treatment for obesity and poor metabolic health, individuals should consider working with integrative practitioners who can help them investigate the root cause of their weight loss resistance, address hormonal imbalances, and lower inflammation
However, a small percentage of people experience persistent fatigue throughout treatment despite implementing all recommended strategies
