Proc Natl Acad Sci USA 94(2):514519 Yang Y, Dieter MZ, Chen Y, Shertzer HG, Nebert DW, Dalton TP (2002) Initial characterization of the glutamate-cysteine ligase modifier subunit Gclm(/) knockout mouse
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These mice had a reductive stress phenotype [46, 47], characterized, in part, by an increased activity of GPx1 and catalase as well as increased GSH/GSSG and a corresponding increased expression of enzymes involved in glutathione biosynthesis and GSSG recycling to GSH
Chronic HPA activation elevates cortisol production, lowering immune responses and the production of proinflammatory cytokines
Progressive Increase: Increase by ~50 mcg every 12 weeks based on response and comfort level
It has become a popular term implying health benefits (which are not supported scientifically), so some brands that have a pH in the 7s use it as well for marketing purposes