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Side Effects: Sedation Fatigue Depression (suicidal tendencies) Parkinsonism symptoms Hypotension Bradycardia Chest pain Gastric ulceration Diarrhea & vomiting Dry mouth Syncope & arrhythmias For more see Cheung & Parmar (2022) Pharmacokinetics: Reserpine readily crosses the blood brain barrier & depletes cerebral catecholamine stores
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However, even when large oral doses are administered, most of the absorbed glutathione remain within the gut luminal cells and only small and transient increase of glutathione occurs in the circulation
Potential complications include marginal ulcer formation (already a bypass risk) and dumping syndrome exacerbation, both manageable with dosing adjustments
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Meta-analyses conclude that GLP-1 RAs improve metabolic and hormonal parameters in PCOS, though the direct contribution to live birth rates remains uncertain
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