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Families should also be referred for genetic counseling

The emergence of peptides in the pharmaceutical business: From exploration to exploitation

Sestili, P., Diamantini, G., Bedini, A., Cerioni, L., Tommasini, I., Tarzia, G., & Cantoni, O

This route of administration has several drawbacks: high doses are required every day (e.g., prednisone 60-100 mg daily as a starting dose, or equivalent doses of other steroids) (11), treatment lasts for several months (at least 5-6 months), recurrences are frequent upon drug tapering or withdrawal, side effects (particularly Cushings syndrome) are frequent (12, 92, 116, 117)