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In the SURPASS program for type 2 diabetes, tirzepatide demonstrated A1C reductions of 2.07-2.59% across doses, with up to 97% of participants achieving A1C below 7.0%

New treatments, including GLP-1 medications like Ozempic, have offered hope to many for weight management and diabetes control

A reduction in receptor reserve could occur, in the absence of net reduction in total receptor number detected by typical ligand-binding assays, if there is redistribution of receptors from the plasma membrane to internal membranes

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Tirzepatide pairs GLP-1 with GIP receptor activation