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GPER-1 belongs to the family of G protein-coupled receptors, and, in humans, its gene is located in chromosome 7p22.3, which encodes a sequence of 375 amino acids with a relative molecular mass of 41 kDa

Mice treated with metformin showed the similar results to those from OA group in the rotarod test (Fig

reported that HIF-1 could modulate the expression of various factors associated with gut microbiota and intestinal barrier integrity (Shao et al., 2018)

Parenteral (non-oral) administration is faster and more efficient than oral supplements and is recommended for the initial or continued treatment of B12 deficiency

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The best choice depends on the delivery method, individual genetics, and clinical goals