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Most diabetes specialists recommend optimizing a single GLP-1 dose before adding a second incretinotropic agent

Robert Lustig, a metabolic scientist at the University of California-San Francisco, told me

How to take Januvia (Sitagliptin) prescription drugs Be sure to read your prescription label and follow the instructions

This is also why nausea tends to spike during the early weeks of treatment or right after a dose increase

The table below shows how many patients reached each weight loss milestone

Genetic research has identified markers associated with varying responses to GLP-1 therapy, including variants in the GLP1R gene, GIPR gene, and metabolic regulators like FTO and MC4R