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The safety and efficacy of gamma frequency auditory and visual stimulation in the treatment of Alzheimer's disease: a systematic review and meta-analysis

targeted the IP3 receptor (IP3R) channels and induced the downstream pro-apoptotic Ca 2+ -signaling pathway via synthesizing a peptide named Bcl-2 IP3 receptor disrupter-2 (BIRD-2) mimicking the structure of the BH4 domain of Bcl-2

However, like any medical treatment, it may have mild side effects and, in rare cases, some risks

PMID 1329770

Someone that's heavier might need a needle that's slightly longer

Research supports the critical window hypothesis HRT initiated within 10 years of menopause onset (or before age 60) provides cardiovascular protective benefits, while initiation much later may not