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Finally, the substrate binds to the protein hydrolysis active site, and its peptide bond is cleaved, resulting in the hydrolysis of the protein substrate into small molecular peptides [38]

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Furthermore, in the case of breast cancer, an HSD has been found to promote tumor progression and lung metastasis, increase the proportion of Th17 cells, and activate the MAPK/ERK signaling pathway in breast cancer cells through the secretion of IL-17F