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Moreover, our data complements previous observations showing that pre-infusion CD19-CAR T cell products of patients in complete response compared to non- or partial responders have higher mitochondrial volume by 3D confocal microscopy 23 , and that mitochondrial transfer enhances CD19-CAR T cell metabolic fitness and antitumor efficacy in a preclinical model 8

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This dual-axis attack on energy balance simultaneously reducing input and increasing output may be responsible for the sustained slope of weight loss that was not observed with single or dual-agonist compounds in comparable timelines

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