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Bcl-2 overexpression has been observed in fibroblasts isolated from aged mice with bleomycin-induced lung fibrosis [15], consistent with this mechanism
Subsequent studies by the same research team found that microglia develop a senescence-like phenotype after engulfing NFT-containing neurons, and they release toxic forms of partially digested tau (74)
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Identification of a CXCR4 Antagonist, a T140 Analog, as an Anti-Rheumatoid Arthritis Agent