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Additional information DISCLOSURE/CONFLICT OF INTEREST Michael Berk declares that over the past three years, he has received compensation from Stanley Medical Research Foundation, MBF, NHMRC, Beyond Blue, Geelong Medical Research Foundation, Bristol Myers Squibb, Eli Lilly, Glaxo SmithKline, Organon, Norvatis, Mayne Pharma and Servier

Environmental factors, including mercury exposure and iron levels, can also interact with genetics

Clinical trials suggest that it often takes several weeks to a few months of consistent, daily supplementation before patients notice significant improvements in baseline energy levels, cognitive clarity, and exercise tolerance

Individual responses vary