Previous preclinical studies showed that in paclitaxel-induced CIPN models, oral melatonin pretreatment significantly reduced paclitaxel-induced mechanical allergic reactions in male and female animals by decreasing paclitaxel-induced 8-isoprostane F2 levels and C-fiber activity-dependent slowing (ADS) in peripheral nerves, and importantly, melatonin cotreatment with breast or ovarian cancer cells alleviated mitochondrial damage without affecting paclitaxel cytotoxicity [44]
Available at: (Accessed June 2, 2022)
Mohiuddin I, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C
Ethics statement Skin biopsy samples used in this manuscript and animal experiments were approved by the local ethics committee and the institutional review board of Huashan Hospital and conducted in accordance with the Helsinki declaration
Rarely, cirrhosis can also lead to hepatocerebral degeneration with encephalopathy which can present with apathy, lethargy, somnolence, and/or extrapyramidal symptoms
A 10mg vial runs $45 to $120