Dose, route, timing, and model artifacts Preclinical doses (for example, T4 at 630 mg/kg in rats, or BPC-157 at microgram-to-nanogram-per-kilogram ranges) do not translate to humans by simple scaling, and route and timing strongly shaped the reported outcomes
Is it the end of the world
Many people also notice improvements in nail strength and skin quality as additional benefits of biotin supplementation
We need to see more data from longer and larger clinical trials, which will likely take years for Roche to conduct
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