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In addition, GH stimulates the IRS1/Akt (Costoya et al., Figure 1)
In addition, new compounds known to stimulate the release of GH, known as GH secretagogues or ghrelin mimetics, are also in clinical development (NCT02558829)
Haemoglobin-bound iron is transported into the intestinal epithelial cells by heme carrier protein 1 (HCP1) that is localised to the intestinal mucosal epithelium
It typically requires multiple injections per day to sustain GH levels
each dose splits ~50/50 between the two peptides