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A weekly injection that reduces your appetite and helps you lose weight

Participants received diet (500 kcal deficit per day) and exercise counseling during 2-week run-in, before being randomly assigned (with a telephone or web-based system) to once-daily subcutaneous liraglutide (1.2, 1.8, 2.4 or 3.0 mg, n =9095), placebo ( n =98) or open-label orlistat (120 mg 3, n =95)

We also thank laboratory members for various technical assistance and helpful discussions

Sub-analyses from trials like LEADER (liraglutide) and REWIND (dulaglutide) have shown modest reductions in high-sensitivity C-reactive protein (hsCRP) and other inflammatory biomarkers among patients treated with these agents

Increased energy levels, better blood sugar control, reduced joint discomfort, and a renewed sense of confidence are commonly reported as the body becomes more metabolically efficient

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