Side effects are generally short-term and manageable
Despite the acknowledged limitations, these two metanalyses reach a consistent conclusion: the combination of SGLT2i and GLP-1RA is associated with significantly lower all-cause mortality and superior cardiorenal outcomes compared to monotherapy in patients with T2DM
[1] [4] Ongoing post-marketing surveillance continues to evaluate real-world cardiovascular outcomes, including heart rate effects in diverse patient populations
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on the contrary, it is dispersed heterogeneously, mainly as single cells, along the epithelium of the GI tract, from the stomach to the rectum with a defined cephalocaudal, crypt-to-villus in the small intestine and crypt-to-surface distribution in the colon ( Despite representing just 1% of the adult gut epithelium, in the last decade it has become clear that the EECs constitute the largest endocrine organ in mammalia ( Collectively, the EECs are responsible for the production of more than 30 different hormones that help to orchestrate the fate of the intermediary metabolism
