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Because limbic structures have significant bidirectional connections with the hypothalamus and autonomic bed nucleus of the stria terminalis, one might speculate that limbic dysregulation may contribute to the often-noted autonomic and neuroendocrine dysregulation in bipolar patients (125)

In summary, a carbon side chain of a certain length is favorable, or at least feasible, for interacting with both GLP-1 and GIPR

doi: 10.1007/s007020100004 120 SchoberA

As a transcription factor, Nrf2 can activate Nrf2-ARE-regulated genes, exerting an inhibitory effect on inflammatory factors and providing a defence against oxidative stress, which is essential for enhancing the antioxidant capacity of cells [111]

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