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It represents a fundamentally different pharmacological strategy, one that early clinical data suggests could nearly double the weight loss seen with semaglutide while simultaneously delivering dramatic improvements in liver fat, metabolic markers, and body composition

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Tirzepatide is also licensed for weight management in adults with obesity or overweight with weight-related comorbidities, though this may be marketed under a different brand name in the UK

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J Neurosci 2008

The crucial role of the substantia nigra dopaminergic neurons in operant conditioning for food emerged from data showing that selective restoration of dopamine production in substantia nigra or its primary terminal target, the dorsal striatum, is sufficient to restore the motivation to work for food in mice that lack dopamine otherwise (Sotak et al., 2005