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Type 2 diabetes mellitus (T2DM) is the predominant form, accounting for over 90% of all diabetes cases globally

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Participants in the oral semaglutide arm underwent a dose-escalation schedule (3 mg daily for 4 weeks, followed by 7 mg daily for 4 weeks, then 14 mg daily for the remainder of the trial) to minimize gastrointestinal side effects

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Structured programs incorporating reduced-calorie diets (typically 500-750 kcal/day deficit), increased physical activity (150 minutes of moderate-intensity exercise weekly for weight loss