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In human thyroid cancer, GPx3 is frequently methylated, and the expression of GPx3 is regulated by methylation of the promoter region, and this methylation is related to tumor size and lymph node metastasis through the inhibition of Wnt/-catenin signaling [100]

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Compared with single-target modulators like genistein or quercetin, curcumins pleiotropic epigenetic actions are accompanied by anti-inflammatory, antioxidant, and anti-metastatic effects

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