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Central Nervous System Effects Amylin receptors in the nucleus accumbens and other limbic regions influence food reward circuitry affecting not just satiety (how full you feel) but also the hedonic aspects of eating (how rewarding food is)

For most people, theyre safe and effective for long-term health and weight management

A sagging or deflated appearance that can catch people off guard

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Because the drug's mechanism of action involves the kidneys, empagliflozin is not advisable for patients with end-stage renal disease, severe renal impairment, or those undergoing dialysis