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[14] It is approved as an antimanic and antiseizure in Japan as well

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10.1001/archpedi.161.4.356

Secondary endpoints included the rate of patients with a weight loss of 10%, monthly headache days (MHD), the rate of patients with a 30% and 50% reduction in MHD, visual outcome parameters, and adverse events (AEs)

Collectively, these analyses highlight coumarin, L-leucine, and related metabolites as promising features associated with ASD-related metabolic alterations that warrant further validation in larger, independent cohorts