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Early cumulative UA contributed more to myocardial infarction risk than later cumulative UA with the same overall cumulative exposure (Tian et al., 2021)
Tendon injuries initially suffer from: Poor blood supply Limited vascularity Slow nutrient delivery In rodent models, BPC-157 appears to: Upregulate VEGFR2 signalling Increase capillary density Improve microvascular perfusion Mechanistically: BPC-157 VEGFR2 activation PI3K/Akt pathway eNOS phosphorylation Increased nitric oxide Improved angiogenesis More vascularity = better nutrient and oxygen delivery to fibroblasts
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JACC Basic Transl Sci 2022, 7(7): 713-715
Ipamorelin reached Phase II trials for an unrelated gastrointestinal condition and was discontinued after the trial did not meet its endpoint
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