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Contribution of mast cell-derived interleukin-1 to uric acid crystal-induced acute arthritis in mice

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In DKD, hyperglycemia induces the overexpression of chemokines and cytokines in damaged glomeruli and renal tubules, which aggravate renal injury through a variety of mechanisms, such as leukocyte infiltration, renal filtration barrier breakdown and mesangial proliferation[97, 98]

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