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Fresh compounded semaglutide should be clear and colorless

10.1056/NEJMoa1607141 N Engl J Med

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or synthesis of the peptide fragment II: synthesis of the peptide fragment IV: Cys19-Gly31

Two carboxyl groups on a side chain disclosed by patent CN111378028A are naked and are not protected by a protective group, the purity of an intermediate obtained in the subsequent coupling reaction with an Arg34GLP-1 (9-37) main peptide chain is not high, only 67.5 percent is obtained, the yield is seriously reduced, and the pH value in the reaction has a large influence on the side chain modification, so that various byproducts which are difficult to remove are easily generated, such as a double-modified impurity byproduct with both the 26 th position and the end position of the main peptide chain modified and a byproduct with the end position of the main peptide chain modified

Signs of dehydration include dark urine, dry mouth, headaches, dizziness, and decreased urine output