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They act as cofactors for enzymes involved in metabolism, nutrient conversion, neurotransmitter production and cellular function

Vitamin B12 is an essential nutrient which is required by the body to make red blood cells and maintain a healthy nervous system

The mouse study reported no observed adverse effects at its tested dose, but that does not establish human safety at any dose or route

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Some of the key signs of low B12 to look out for include: Muscle weakness Numbness and tingling in the hands and feet Difficulty walking Nausea Weight loss Irritability Fatigue Rapid heart rate (7) One of the other tell-tale symptoms of a B12 deficiency is constant fatigue or being tired all the time, which can also manifest as sleep disturbances, including insomnia in some people, often requiring sleep medications