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doi: 10.3390/ijms21218234 147

MASH happens when excess fat gathers in the liver and causes damage to organs

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Although the increase is small, it tends to persist during treatment

As a dual GLP-1 and GIP receptor agonist, Tirzepatide affects multiple pathways simultaneously: It slows gastric emptying, enhances insulin secretion in a glucose-dependent manner, suppresses glucagon secretion, and powerfully suppresses appetite

J Cell Biol 2001