If maximum weight loss is the goal and you have no contraindications, GLP-1 medications are almost always the first-line recommendation in current obesity medicine guidelines
Trials 38 , 3750 (2014)
Regular meals and snacks protect lean mass and prevent famine signaling
Higuchi, "Ubiquinol-10 Supplementation Activates Mitochondria Functions to Decelerate Senescence in Senescence-Accelerated Mice", Antioxid
Misra, collagen production can be affected while on GLP-1s, which can lead to crepey skin
In humans, GLP-1As have already been related to an increase in neoplasms development, such as pancreatic adenocarcinoma and thyroid C-cell tumor, but recent meta-analyses of randomized controlled trials failed to show any significant increase in cancer risk (Cao, Yang & Zhou, 2019