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Allyl-substituted polysulfides undergo nucleophilic substitution at the allyl substituent's -carbon to form hydropolysulfide (RSnH), a key intermediate in H 2 S synthesis

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The mechanisms underlying 3-HK toxicity remain incompletely defined, but its strong propensity for oxidation makes it a potent generator of ROS

Clin J Am Soc Nephrol 6:3039 Wautier MP, Chappey O, Corda S, Stern DM, Schmidt AM, Wautier JL (2001) Activation of NADPH oxidase by AGE links oxidant stress to altered gene expression via RAGE