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Additionally, pancreatic cancer-related studies have shown that Ex-4 treatment reduces the mRNA expression levels of pancreatic stellate cell (PSC) activation markers -SMA and Coll-I [39]

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Our earlier metabolic phenotyping work provides support for this vision (16, 26)

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Indeed, after 60 min of the glucose challenge, and therefore 65 min after dosing, 1 showed no more significant effect compare to the vehicle while 14 was still active, as expected from the blood glucose study (Fig