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This is when lactic acid builds up in the blood

These delays highlight the structural barriers that can slow adoption in populations with higher rates of comorbidities

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The energy requirements of the brain are very high due to energy intensive processes that are essential for healthy brain function, such as maintenance of ion gradients, cellular signalling, synaptic vesicle trafficking, and uptake and recycling of neurotransmitters [190]

This upregulation of VEGF was accompanied by the formation of angiogenic factors, highlighting the intricate interplay between vascular remodeling and neuroinflammation in EAE pathology

Lancet Diabetes Endocrinol 13, 15-28 (2025)