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134 A randomized placebo-controlled trial in 120 subjects who described their sleep as unsatisfactory found treatment with 14 mg or 28 mg of a standardized saffron extract, taken one hour before bedtime for 28 days, improved subjective sleep quality and mood scores

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Accordingly, inhibition of the main enzyme (asparagine synthetase- ASNS) involved in asparagine biosynthesis can also restrain tumor cells development/proliferation by multiple mechanisms, including (i) weakening Nucks1 effects in the proliferation of osteosarcoma cells