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Suppression of NFS1 alone does not induce ferroptosis, but when cells produce large amounts of ROS, iron starvation induced by inhibition of NFS1 promotes ferroptosis
In addition, current literature reveals significant gaps regarding the interaction between antioxidant supplements and cancer therapies
1 M with Fer-1
Key antioxidant enzymes, such as glutathione peroxidase (GPX1), glutathione reductase (GSR), superoxide dismutase (SOD1 and SOD2), and members of the thioredoxin family, exhibit reduced expression in oocytes from aged animals
Supplementation with gamma-glutamylcysteine has been demonstrated in a human clinical trial to increase cellular glutathione levels regardless of its initial (basal) concentration
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