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The nervous system may be protected by its neuroprotective qualities

The hypothesized mechanism involves the modulation of neurotransmitters and inflammation, as well as the potential neuroprotective effects of GLP-1 receptor agonists

GLP-1 3 also functions as a neurotransmitter and is synthesized in the brain as part of the central nervous system (CNS)

The increased risk of amputation seen in the large, long-term Canagliflozin Cardiovascular Assessment Study (CANVAS) trial for canagliflozin, and select observational studies, merits further research but overall, there is currently no consistent evidence of SGLT2i exposure and increased risk of amputation

It is these flutters that is known as heart palpitations