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Tan Q, Akindehin SE, Orsso CE, et al

Subsequent experiments from the same research group revealed that U397 cells pre-treated with AST (10 mol/L) for 1 h reduced lipopolysaccharide-induced superoxide production and maintained the activity of intracellular antioxidant enzymes [68]

This is significant for combination protocols because it suggests that adding cagrilintide to retatrutide may not dramatically increase the gastrointestinal burden, provided the titration is managed correctly

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